WDR5 WIN site inhibitor C3 ( —— )

Catalog No. M17064 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

WDR5 WIN site inhibitor C3
Note

Research use only, not for human use.
Brief Description

WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM.
Description

WDR5 WIN site inhibitor C3 is a potent, specific WIN (WDR5 interaction) site inhibitor of WDR5 with Kd of 1.3 nM; inhibits leukemia cell lines in vitro (MV4:11 cell GI50=6.67 uM), rapidly displace WDR5 from chromatin and decrease the expression of associated genes, causing translational inhibition, nucleolar stress, and p53 induction.
Synonyms

——
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

HMTase
Research Area

——
Indication

——

CAS Number

--
Formula Weight

386.43
Molecular Formula

C20H23FN4O3
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

3-(((4,5-dihydro-1H-imidazol-2-yl)amino)methyl)-N-(3,5-dimethoxybenzyl)-4-fluorobenzamide

1. Aho ER, et al. Cell Rep. 2019 Mar 12;26(11):2916-2928.e13.

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